Concepedia

A strategy of local hydrogen capture and catalytic hydrogenation for enhanced therapy of chronic liver diseases

Geru Tao, Feng Liu, Zhaokui Jin, Boyan Liu, Hao Wang, Daosheng Li, Wei Tang, Yuan Chen, Qianjun He, Shucun Qin

Theranostics · 2023 · 27 citations · 33 references

Open access

Concepts

PharmacyPharmaceuticsPharmacologyDrug DeliveryNanoparticle Drug DeliveryTargeted Drug DeliveryHepatic MetabolismLiver DiseaseMetabolic Liver DiseaseAnti-inflammatory TherapeuticsHydrogenationHydrogenation CatalysisHydrogenation ReactionsLiver-specific Drug TargetingLiver-targeted ProdrugsLocalized Hepatic Therapy

Abstract

Our study verified a catalytic strategy of combining PdH nanoparticles and hydrogen inhalation, which exhibited enhanced anti-inflammatory effect for CLD treatment. The proposed catalytic strategy will open a new window to realize safe and efficient CLD treatment.

References

33

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Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi et al. · Nature Medicine · 2007 · 2.5K citations

Life Sciences, Biochemistry, Pharmacology +13

Liver cirrhosis

The Lancet · 2021 · 1.5K citations

Medicine, Surgery, Hepatology +13

A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer

Takuma Tsuchida, Youngmin A. Lee, Naoto Fujiwara et al. · Journal of Hepatology · 2018 · 561 citations · Full text

Medicine, Nutritional Sciences, Inflammation +9

Hydrogen storage in Pd nanocrystals covered with a metal–organic framework

Guangqin Li, Hirokazu Kobayashi, Jared M. Taylor et al. · Nature Materials · 2014 · 470 citations

Natural Sciences, Materials Engineering, Materials Science +13

Nanosize Effects on Hydrogen Storage in Palladium

Miho Yamauchi, Ryuichi Ikeda, Hiroshi Kitagawa et al. · The Journal of Physical Chemistry C · 2008 · 389 citations

Natural Sciences, Materials Engineering, Materials Science +17