Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.

Effects of Losartan on Renal and Cardiovascular Outcomes in Patients with Type 2 Diabetes and Nephropathy

Barry M. Brenner, Mark E. Cooper, Dick de Zeeuw et al. · New England Journal of Medicine · 2001 · 7.4K citations · Full text

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

Hiderou Yoshida, Toshie Matsui, Akira Yamamoto et al. · Cell · 2001 · 4K citations · Full text

Transcriptional Regulation, Signal Transduction, Molecular Regulation +9

Diabetic Kidney Disease

Radica Z. Alicic, Michele T. Rooney, Katherine R. Tuttle · Clinical Journal of the American Society of Nephrology · 2017 · 2.6K citations · Full text

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi, Moon-Il Kang, Hiromi Okawa et al. · Molecular and Cellular Biology · 2004 · 2.2K citations · Full text

Molecular Biology, Redox Biology, Oxidative Stress +18

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

Kevin Travers, Christopher K. Patil, Lisa Wodicka et al. · Cell · 2000 · 2K citations · Full text

Reductive Stress, Protein Function, Protein Folding +11