Synergistic anticancer activity of combined ATR and ribonucleotide reductase inhibition in Ewing's sarcoma cells

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Philip M. Reaper, Matthew R. Griffiths, Joanna Long et al. · Nature Chemical Biology · 2011 · 631 citations

Tumor Biology, P53-deficient Cancer Cells, Selective Killing +9

The Genomic Landscape of Pediatric Ewing Sarcoma

Brian D. Crompton, Chip Stewart, Amaro Taylor‐Weiner et al. · Cancer Discovery · 2014 · 561 citations

Genomic Landscape of Ewing Sarcoma Defines an Aggressive Subtype with Co-Association of <i>STAG2</i> and <i>TP53</i> Mutations

Franck Tirode, Didier Surdez, Xiaotu Ma et al. · Cancer Discovery · 2014 · 560 citations · Full text

Aberrant expression of the p53 oncoprotein is a common feature of a wide spectrum of human malignancies.

Jiří Bártek, Jiřina Bártková, Bořivoj Vojtěšek et al. · PubMed · 1991 · 510 citations

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

Vincenzo D’Angiolella, Valerio Donato, Frances M. Forrester et al. · Cell · 2012 · 408 citations · Full text

Reductive Stress, Genome Instability, Natural Sciences +7