Concepedia

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Yibo Zhao, Longming Chen, Junyi Chen, Jian Li, Qingbin Meng, Andrew C.‐H. Sue, Chunju Li

Chemical Communications · 2023 · 35 citations · 27 references

DOI

Concepts

Abstract

]arene derivative functionalised with sulfate acid ester groups. This water-soluble terphen[3]arene host effectively encapsulates a multitude of neuromuscular blocking agents (NMBAs) with high affinity, showing great potential as a NMBAs reversal agent in pharmaceutical research.

References

27

Residual neuromuscular block is a risk factor for postoperative pulmonary complications A prospective, randomised, and blinded study of postoperative pulmonary complications after atracurium, vecuronium and pancuronium

Hans E. Berg, J. Viby‐Mogensen, Jakob Roed et al. · Acta Anaesthesiologica Scandinavica · 1997 · 656 citations

, , +10

A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

A. Bom, Mark Philip Bradley, Ken Cameron et al. · Angewandte Chemie International Edition · 2002 · 457 citations

, , +15

Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER)

Sachin Kheterpal, Michelle T. Vaughn, Timur Dubovoy et al. · Anesthesiology · 2020 · 306 citations · Full text

, , +11

THE PHARMACOLOGICAL ACTIONS OF POLYMETHYLENE BISTRIMETHYLAMMONIUM SALTS

W. D. M. Paton, Eleanor Zaimis · British Journal of Pharmacology · 1997 · 244 citations · Full text

, , +2

Biphen[<i>n</i>]arenes: Modular Synthesis, Customizable Cavity Sizes, and Diverse Skeletons

Zhiyuan Zhang, Chunju Li · Accounts of Chemical Research · 2022 · 184 citations

, , +16