Concepedia

Intravitreal Administration of AAV2-SIRT1 Reverses Diabetic Retinopathy in a Mouse Model of Type 2 Diabetes

Yvonne Adu-Agyeiwaah, Cristiano Pedrozo Vieira, Bright Asare‐Bediako, Sergio Li Calzi, Mariana Dupont, Jason L. Floyd, Sanford L. Boye, Vince A. Chiodo, Julia V. Busik, Maria B. Grant

Translational Vision Science & Technology · 2023 · 11 citations · 33 references

DOIFull text

Open access

Abstract

AAV2-SIRT1 gene therapy represents a beneficial approach for the treatment of chronic retinal conditions such as DR.

References

33

Treatment of Leber Congenital Amaurosis Due to <i>RPE65</i> Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

William W. Hauswirth, Tomás S. Alemán, Shalesh Kaushal et al. · Human Gene Therapy · 2008 · 937 citations · Full text

Retinal gene therapy in patients with choroideremia: initial findings from a phase 1/2 clinical trial

Robert E. MacLaren, Markus Groppe, Alun R. Barnard et al. · The Lancet · 2014 · 769 citations · Full text

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Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

Akiko Satoh, Cynthia S. Brace, Nick Rensing et al. · Cell Metabolism · 2013 · 718 citations · Full text

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The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

Michael W. McBurney, Xiaofeng Yang, Karen Jardine et al. · Molecular and Cellular Biology · 2002 · 616 citations · Full text

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Glial reactivity, an early feature of diabetic retinopathy.

Elisabeth Rungger‐Brändle, A. Dosso, P Leuenberger · PubMed · 2000 · 513 citations