Tomás S. Alemán

Gene therapy restores vision in a canine model of childhood blindness

Gregory M. Acland, Jharna Ray, Qí Zhāng et al. · Nature Genetics · 2001 · 1.2K citations

Optogenetics, Gene Therapies, Developmental Biology +8

Treatment of Leber Congenital Amaurosis Due to <i>RPE65</i> Mutations by Ocular Subretinal Injection of Adeno-Associated Virus Gene Vector: Short-Term Results of a Phase I Trial

William W. Hauswirth, Tomás S. Alemán, Shalesh Kaushal et al. · Human Gene Therapy · 2008 · 937 citations · Full text

Human gene therapy for RPE65 isomerase deficiency activates the retinoid cycle of vision but with slow rod kinetics

Artur V. Cideciyan, Tomás S. Alemán, Sanford L. Boye et al. · Proceedings of the National Academy of Sciences · 2008 · 660 citations · Full text

Slow Rod Kinetics, Gene Therapies, Ocular Disease +12

Long-Term Restoration of Rod and Cone Vision by Single Dose rAAV-Mediated Gene Transfer to the Retina in a Canine Model of Childhood Blindness

Gregory M. Acland, Jean Bennett, Tomás S. Alemán et al. · Molecular Therapy · 2005 · 464 citations · Full text

Human <i>RPE65</i> Gene Therapy for Leber Congenital Amaurosis: Persistence of Early Visual Improvements and Safety at 1 Year

Artur V. Cideciyan, William W. Hauswirth, Tomás S. Alemán et al. · Human Gene Therapy · 2009 · 311 citations · Full text