Systematic engineering of Escherichia coli for efficient production of nicotinamide riboside from nicotinamide and 3-cyanopyridine

Multigene Editing in the Escherichia coli Genome via the CRISPR-Cas9 System

Yu Jiang, Biao Chen, Chunlan Duan et al. · Applied and Environmental Microbiology · 2015 · 1.3K citations · Full text

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Carles Cantó, Riekelt H. Houtkooper, Eija Pirinen et al. · Cell Metabolism · 2012 · 1.2K citations · Full text

Obesity, Metabolic Syndrome, High-fat Diet-induced Obesity +9

NAD ⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice

Hongbo Zhang, Dongryeol Ryu, Yibo Wu et al. · Science · 2016 · 1.2K citations · Full text

Aging, Anti-aging, Cell Death +19

Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

Paweł Bieganowski, Charles Brenner · Cell · 2004 · 742 citations · Full text

Biology, Nicotinamide Riboside, Biosynthesis +6

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

Peter Belenky, Frances G. Racette, Katrina L. Bogan et al. · Cell · 2007 · 405 citations · Full text

Lifespan Extension, Extends Lifespan, Molecular Biology +8