Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutations

References

Page 1

	Year	Citations
<i>MTAP</i> deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells Gregory V. Kryukov, Frederick H. Wilson, Jason R. Ruth, Science Epigenetic ChangeMolecular BiologyPrmt5 Arginine MethyltransferaseCancer BiologyEpigenetics	2016	608
Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine Lawrence M. Gelbert, Shufen Cai, Xi Lin, Investigational New Drugs	2014	555
Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5 Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach, Science	2016	538
Landscape of somatic mutations and clonal evolution in mantle cell lymphoma Rafael Valdés‐Mas, Alba Navarro, Itziar Salaverría, Proceedings of the National Academy of Sciences	2013	515
Arginine methylation regulates the p53 response Martin Jansson, Stephen T. Durant, Er-Chieh Cho, Nature Cell Biology ChromatinTranscriptional RegulationMedicineEpigenetic ChangeEpigenomics	2008	453
MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis Katya Marjon, Michael J. Cameron, Phong Quang, Cell Reports	2016	415
Crystal structure of the human PRMT5:MEP50 complex Stephen Antonysamy, Zahid Bonday, Robert M. Campbell, Proceedings of the National Academy of Sciences ChromatinCrystal StructureProtein FunctionChromatin StructureBiochemistry	2012	358
Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance Valentina Migliori, Julius Müller, Sameer Phalke, Nature Structural & Molecular Biology Histone ModificationsEpigenetic ChangeGeneticsMolecular BiologyEuchromatin Maintenance	2012	332
Regulation of constitutive and alternative splicing by PRMT5 reveals a role for <i>Mdm4</i> pre-mRNA in sensing defects in the spliceosomal machinery Marco Bezzi, Shun Xie Teo, Julius Müller, Genes & Development	2013	311
Mechanism of p53 stabilization by ATM after DNA damage Qian Cheng, Jiandong Chen Cell Cycle Dna DamageApoptosisCell DeathMolecular BiologyCancer Biology	2010	245

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