Exploiting PRMT5 as a target for combination therapy in mantle cell lymphoma characterized by frequent ATM and TP53 mutations

<i>MTAP</i> deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

Gregory V. Kryukov, Frederick H. Wilson, Jason R. Ruth et al. · Science · 2016 · 608 citations

Epigenetic Change, Molecular Biology, Prmt5 Arginine Methyltransferase +20

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

Lawrence M. Gelbert, Shufen Cai, Xi Lin et al. · Investigational New Drugs · 2014 · 555 citations · Full text

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach et al. · Science · 2016 · 538 citations

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

Rafael Valdés‐Mas, Alba Navarro, Itziar Salaverría et al. · Proceedings of the National Academy of Sciences · 2013 · 515 citations · Full text

Arginine methylation regulates the p53 response

Martin Jansson, Stephen T. Durant, Er-Chieh Cho et al. · Nature Cell Biology · 2008 · 453 citations

Chromatin, Transcriptional Regulation, Medicine +6