Concepedia

3,4-Dimethoxychalcone, a caloric restriction mimetic, enhances TFEB-mediated autophagy and alleviates pyroptosis and necroptosis after spinal cord injury

Haojie Zhang, Gaoxiang Yu, Yibo Geng, Junsheng Lou, Jianjun Qi, Yituo Chen, Feida Li, Hantao Ye, Haiwei Ma, Hui Xu,

Theranostics · 2023 · 95 citations · 44 references

DOIFull text

Open access

Concepts

Abstract

3,4-DC promotes functional recovery by upregulating TFEB-mediated autophagy and inhibiting pyroptosis and necroptosis after SCI, which may have potential clinical application value.

References

44

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Rongbin Zhou, Aubry Tardivel, Bernard Thorens et al. · Nature Immunology · 2009 · 2.7K citations

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Basso Mouse Scale for Locomotion Detects Differences in Recovery after Spinal Cord Injury in Five Common Mouse Strains

D. Michele Basso, Lesley C. Fisher, Aileen J. Anderson et al. · Journal of Neurotrauma · 2006 · 1.8K citations

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Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

Diego L. Medina, Simone Di Paola, Ivana Peluso et al. · Nature Cell Biology · 2015 · 1.4K citations

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

Zhenyu Cai, Siriporn Jitkaew, Jie Zhao et al. · Nature Cell Biology · 2013 · 1.3K citations · Full text

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Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

Melanie Fritsch, Saskia Diana Günther, Robin Schwarzer et al. · Nature · 2019 · 1.1K citations

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