HIF-1α/Malat1/miR-141 Axis Activates Autophagy to Increase Proliferation,Migration, and Invasion in Triple-negative Breast Cancer

Abstract

miR-141-3p could suppress autophagy and inhibit proliferation, migration, and invasion by targeting Malat1 in TNBC cells under hypoxia. The existence of the HIF-1α/Malat1/miR-141 axis plays a vital role in the development of TNBC and may be a target for the diagnosis and treatment of TNBC.