Concepedia

Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug

BoRa Lee, Dae Gyu Kim, Aram Lee, Young Mi Kim, Lianji Cui, Sung‐Hoon Kim, Inhee Choi

Journal of Enzyme Inhibition and Medicinal Chemistry · 2022 · 14 citations · 18 references

DOIFull text

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Concepts

Abstract

was found to be a degrader of AIMP2-DX2. Together, these findings demonstrate that our PROTAC technology targeting AIMP2-DX2 would be a potential new strategy for future lung cancer treatment.

References

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