CASTp: Computed Atlas of Surface Topography of proteins

TLDR

CASTp is an online resource that locates, delineates, and measures concave surface regions—pockets on protein surfaces and interior voids—on three‑dimensional protein structures. It measures pocket and void area and volume analytically using solvent‑accessible (Richards) and molecular (Connolly) surface models, and offers a graphical interface with interactive visualization and on‑the‑fly calculation for user‑uploaded structures. CASTp enables the study of protein surface features and functional regions, is updated daily, and is available at http://cast.engr.uic.edu.

Abstract

Computed Atlas of Surface Topography of proteins (CASTp) provides an online resource for locating, delineating and measuring concave surface regions on three-dimensional structures of proteins. These include pockets located on protein surfaces and voids buried in the interior of proteins. The measurement includes the area and volume of pocket or void by solvent accessible surface model (Richards' surface) and by molecular surface model (Connolly's surface), all calculated analytically. CASTp can be used to study surface features and functional regions of proteins. CASTp includes a graphical user interface, flexible interactive visualization, as well as on-the-fly calculation for user uploaded structures. CASTp is updated daily and can be accessed at http://cast.engr.uic.edu.