Universal DNAzyme walkers-triggered CRISPR-Cas12a/Cas13a bioassay for the synchronous detection of two exosomal proteins and its application in intelligent diagnosis of cancer

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.4K citations

Life Sciences, Genetics, Molecular Biology +13

Nucleic acid detection with CRISPR-Cas13a/C2c2

Jonathan S. Gootenberg, Omar O. Abudayyeh, Jeong Wook Lee et al. · Science · 2017 · 3.8K citations · Full text

Life Sciences, Biotechnology, Genetics +17

CRISPR-Cas9 In Vivo Gene Editing for Transthyretin Amyloidosis

Julian D. Gillmore, Ed Gane, Jörg Täubel et al. · New England Journal of Medicine · 2021 · 1.6K citations · Full text

Life Sciences, Genetics, Molecular Biology +14

SHERLOCK: nucleic acid detection with CRISPR nucleases

Max J. Kellner, Jeremy Koob, Jonathan S. Gootenberg et al. · Nature Protocols · 2019 · 1.6K citations · Full text

Life Sciences, Biotechnology, Molecular Biology +13

Functional DNA Regulated CRISPR-Cas12a Sensors for Point-of-Care Diagnostics of Non-Nucleic-Acid Targets

Ying Xiong, Ying Xiong, Jingjing Zhang et al. · Journal of the American Chemical Society · 2019 · 671 citations · Full text

Engineering, Biotechnology, Molecular Biology +17