Parkin drives <scp>pS65‐Ub</scp> turnover independently of canonical autophagy in <i>Drosophila</i>

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Tohru Kitada, Shuichi Asakawa, Nobutaka Hattori et al. · Nature · 1998 · 5.2K citations

Molecular Neuroscience, Mendelian Disorder, Genetic Disorder +7

Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips

Juri Rappsilber, Matthias Mann, Yasushi Ishihama · Nature Protocols · 2007 · 4.7K citations

Proteomic Technology, Engineering, Biochemistry +8

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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Cell Autophagy, Mitophagy, Mitochondrial Function +11

Hereditary Early-Onset Parkinson's Disease Caused by Mutations in <i>PINK1</i>

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Neurodegenerative Diseases, Mitophagy, Mitochondrial Function +14

The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy

Michael Lazarou, Danielle A. Sliter, Lesley A. Kane et al. · Nature · 2015 · 2.6K citations

Cell Autophagy, Mitophagy, Ubiquitin Kinase Pink1 +9