Enhanced bioavailability and hepatoprotective effect of silymarin by preparing silymarin-loaded solid dispersion formulation using freeze-drying method

Identification of hepatoprotective flavonolignans from silymarin

Stephen J. Polyak, Chihiro Morishima, Volker Lohmann et al. · Proceedings of the National Academy of Sciences · 2010 · 312 citations · Full text

Veterinary Medicine, Medicinal Chemistry, Pharmacology +15

Commonly used surfactant, Tween 80, improves absorption of P-glycoprotein substrate, digoxin, in rats

Hongjian Zhang, Ming Yao, Richard A. Morrison et al. · Archives of Pharmacal Research · 2003 · 245 citations

Pharmacy, Pharmacokinetics, Pharmacology +11

Analysis of silibinin in rat plasma and bile for hepatobiliary excretion and oral bioavailability application

Jhy-Wen Wu, Lie-Chwen Lin, Shih‐Chieh Hung et al. · Journal of Pharmaceutical and Biomedical Analysis · 2007 · 188 citations

Pharmacy, Biochemistry, Pharmacokinetics +13

Pharmacokinetics and Metabolic Profile of Free, Conjugated, and Total Silymarin Flavonolignans in Human Plasma after Oral Administration of Milk Thistle Extract

Zhiming Wen, Todd Dumas, Sarah J. Schrieber et al. · Drug Metabolism and Disposition · 2007 · 171 citations

Pharmacy, Pharmacokinetics, Pharmacology +13

The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats

Aleksandar Rašković, Nebojša Stilinović, Jovanka Kolarović et al. · Molecules · 2011 · 171 citations · Full text

Pharmacy, Pharmacology, Toxicology +16