Insulin induces insulin receptor degradation in the liver through EphB4

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

James R. Gavin, Jesse Roth, David M. Neville et al. · Proceedings of the National Academy of Sciences · 1974 · 1K citations · Full text

Life Sciences, Biochemistry, Endocrinology +17

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

Weimin He, Yaacov Barak, Andrea L. Hevener et al. · Proceedings of the National Academy of Sciences · 2003 · 964 citations · Full text

Medicine, Endocrinology, Pharmacology +17

Insulin interactions with its receptors: Experimental evidence for negative cooperativity

Pierre De Meyts, Jesse Roth, David M. Neville et al. · Biochemical and Biophysical Research Communications · 1973 · 723 citations

Life Sciences, Biochemistry, Endocrinology +16

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

Pingping Li, Da Young Oh, Gautam Bandyopadhyay et al. · Nature Medicine · 2015 · 314 citations · Full text

Life Sciences, Cell Biology, Endocrinology +14

Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance

Pingping Li, Shuainan Liu, Min Lü et al. · Cell · 2016 · 301 citations · Full text

Life Sciences, Cell Biology, Endocrinology +14