Concepedia

Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment

Abdulkarim Najjar, Ans Punt, John F. Wambaugh, Alicia Paini, Corie A. Ellison, Styliani Fragki, Enrica Bianchi, Fagen Zhang, Joost Westerhout, Dennis C. Mueller,

Archives of Toxicology · 2022 · 37 citations · 72 references

Open access

References

72

Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions

Trudy Rodgers, Malcolm Rowland · Journal of Pharmaceutical Sciences · 2006 · 919 citations

Physiologically Based Pharmacokinetics, Pharmacokinetic Modeling, Physiologically-based Pharmacokinetic Modeling +12

Basic Concepts in Physiologically Based Pharmacokinetic Modeling in Drug Discovery and Development

HM Jones, K Rowland‐Yeo · CPT Pharmacometrics & Systems Pharmacology · 2013 · 561 citations · Full text

Integration of Dosimetry, Exposure, and High-Throughput Screening Data in Chemical Toxicity Assessment

Barbara A. Wetmore, John F. Wambaugh, Stephen Ferguson et al. · Toxicological Sciences · 2011 · 401 citations

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

Lars Kuepfer, Christoph Niederalt, Thomas Wendl et al. · CPT Pharmacometrics & Systems Pharmacology · 2016 · 382 citations · Full text

Engineering, Modeling Method, Physiologically-based Pharmacokinetic Modeling +26

Penetration of industrial chemicals across the skin: A predictive model

Richard H. Guy, Russell O. Potts · American Journal of Industrial Medicine · 1993 · 373 citations