Concepedia

Chemical-specific Parameterization

Chemical-Specific Parameterization is a physiologically based toxicokinetic modeling procedure that involves the determination and integration of chemical-dependent parameters—such as partition coefficients, metabolic rate constants, and protein binding affinities—derived from empirical data or in silico predictions to enable accurate, compound-specific simulation of absorption, distribution, metabolism, and excretion dynamics in vivo.

46

Publications

4.1K

Citations

190

Authors

87

Institutions

Publications per year

2017–2026

18

Parents

Publications

46

The use of global and local molecular parameters for the analysis of the gas-phase basicity of amines

Weitao Yang, Wilfried J. Mortier · Journal of the American Chemical Society · 1986 · 1.9K citations

, , +6

Technical basis for narcotic chemicals and polycyclic aromatic hydrocarbon criteria. I. Water and tissue

Dominic M. Di Toro, Joy A. McGrath, David J. Hansen · Environmental Toxicology and Chemistry · 2000 · 407 citations

, , +16

Determination of new ASOG parameters.

Katsumi Tochigi, Detlef Tiegs, Jürgen Gmehling et al. · JOURNAL OF CHEMICAL ENGINEERING OF JAPAN · 1990 · 266 citations · Full text

, , +9

The Refinement of Uncertainty/Safety Factors in Risk Assessment by the Incorporation of Data on Toxicokinetic Variability in Humans

J.L.C.M. Dorne, A.G. Renwick · Toxicological Sciences · 2005 · 132 citations

, , +17

Bayesian evaluation of a physiologically based pharmacokinetic (PBPK) model for perfluorooctane sulfonate (PFOS) to characterize the interspecies uncertainty between mice, rats, monkeys, and humans: Development and performance verification

Wei‐Chun Chou, Zhoumeng Lin · Environment International · 2019 · 95 citations · Full text

, , +17

1–5 of 46

Authors

190

  1. JF
    John F. Wambaugh

    Environmental Protection Agency, United States

    5 publications · 263 citations

    5

    h-index

  2. RT
    Rogelio Tornero‐Velez

    Environmental Protection Agency, United States

    3 publications · 152 citations

    3

    h-index

  3. DM
    Dominic M. Di Toro

    University of Delaware, United States

    2 publications · 426 citations

    2

    h-index

  4. JP
    J. Phillip Bowen

    University of Georgia, United States

    2 publications · 35 citations

    2

    h-index

  5. RG
    Robert G. Pearce

    Environmental Protection Agency, United States

    2 publications · 118 citations

    2

    h-index

1–5 of 190

Institutions

87

  1. Research Triangle Park Foundation

    Durham, United States

    8 h-index

    36 publications

    1.5K citations

  2. Environmental Protection Agency

    Washington, United States

    8 h-index

    41 publications

    1.8K citations

  3. Oak Ridge Associated Universities

    Oak Ridge, United States

    4 h-index

    10 publications

    577 citations

  4. Oak Ridge Institute for Science and Education

    Oak Ridge, United States

    4 h-index

    10 publications

    577 citations

  5. Wageningen University & Research

    Wageningen, The Netherlands

    2 h-index

    7 publications

    219 citations

  6. University of Southampton

    Southampton, United Kingdom

    2 h-index

    3 publications

    277 citations

  7. Radboud University Nijmegen

    Nijmegen, The Netherlands

    2 h-index

    5 publications

    112 citations

  8. North China Electric Power University

    Beijing, China

    2 h-index

    5 publications

    173 citations

1–8 of 87

Venues

  1. Toxicological Sciences

    5 publications · 347 citations

    5

    h-index

  2. Environmental Toxicology and Chemistry

    5 publications · 488 citations

    5

    h-index

  3. Environmental Science & Technology

    3 publications · 100 citations

    3

    h-index

  4. Industrial & Engineering Chemistry Research

    2 publications · 83 citations

    2

    h-index

  5. Environment International

    2 publications · 114 citations

    2

    h-index

1–5