Concepedia

C3aR contributes to unilateral ureteral obstruction-induced renal interstitial fibrosis via the activation of the NLRP3 inflammasome

Danyu You, Mengjie Weng, Xiaoting Wu, Kun Nie, Jiong Cui, Yi Chen, Liyan Yang, Jianxin Wan

Life Sciences · 2022 · 15 citations · 18 references

DOI

Concepts

References

18

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

, , +15

Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy

Robert L. Chevalier, Michael S. Forbes, Barbara A. Thornhill · Kidney International · 2009 · 1K citations

, , +15

The NLRP3 Inflammasome Promotes Renal Inflammation and Contributes to CKD

Akosua Vilaysane, Justin Chun, Mark E. Seamone et al. · Journal of the American Society of Nephrology · 2010 · 584 citations · Full text

, , +17

C3a modulates IL-1β secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation

Elham Asgari, Gaëlle Le Friec, Hidekazu Yamamoto et al. · Blood · 2013 · 305 citations

, , +14

Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis

Bo Zhang, Xiang Chen, Ru Feng et al. · Cell Death and Disease · 2021 · 218 citations · Full text

, , +13