Autophagy · 2022 · 37 citations · 33 references
Life SciencesCardiologyCell BiologyAutophagyCell SignalingSignal TransductionAutophagy In Stress ResponsesAutophagy ModulationAutophagy RegulationAutophagy Signaling PathwaysCardiovascular PathophysiologyCardiovascular PhysiologyAutophagy In HypoxiaAutophagy In The HeartAutophagy ModulatorsAutophagy PathwayCardiac Fibrosis ModulationProtein Kinase A SignalingProtein Kinase G SignalingVascular Integrity Preservation
knockout mice undergoing ischemia-reperfusion (I/R) show increased infarct size and reduced autophagy. Reactivation of autophagy by Tat-Beclin D11 limits I/R injury. We also found that the protective effects of NPPA in reducing infarct size are abrogated in the presence of autophagy inhibition. Mechanistically, we found that NPPA stimulates autophagy through the activation of TFEB (transcription factor EB). Our data suggest that NPPA is a novel extracellular regulator of autophagy in the heart.
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Autophagy in the Pathogenesis of Disease
Beth Levine, Guido Kroemer · Cell · 2008 · 7K citations · Full text
TFEB Links Autophagy to Lysosomal Biogenesis
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