Concepedia

Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

Torsten P. M. Scheithauer, Hilde Herrema, Hongbing Yu, Guido J. Bakker, Maaike Winkelmeijer, Galina Soukhatcheva, Derek L. Dai, Caixia Ma, Stefan R. Havik, Manon Balvers,

Gut Microbes · 2022 · 28 citations · 54 references

DOIFull text

Open access

Concepts

Abstract

in mice. We postulate that increased systemically disseminated flagellin in T2D is a contributing factor to beta-cell failure in time and represents a novel therapeutic target.

References

54

Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform

James J. Kozich, Sarah L. Westcott, Nielson T. Baxter et al. · Applied and Environmental Microbiology · 2013 · 7.5K citations · Full text

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Site-directed mutagenesis by overlap extension using the polymerase chain reaction

Steffan N. Ho, Henry D. Hunt, Robert M. Horton et al. · Gene · 1989 · 7.5K citations

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A metagenome-wide association study of gut microbiota in type 2 diabetes

Junjie Qin, Yingrui Li, Zhiming Cai et al. · Nature · 2012 · 7K citations · Full text

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Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

Osamu Takeuchi, Katsuaki Hoshino, Taro Kawai et al. · Immunity · 1999 · 3.4K citations · Full text

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From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

Ralph A. DeFronzo · Diabetes · 2009 · 3K citations · Full text

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