Concepedia

Unmasking Schizophrenia: Synaptic Pruning in Adolescence Reveals a Latent Physiological Vulnerability in Prefrontal Recurrent Networks

Matthew V. Chafee, Bruno B. Averbeck

Biological Psychiatry · 2022 · 24 citations · 5 references

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References

5

Schizophrenia risk from complex variation of complement component 4

Aswin Sekar, Heather de Rivera, Avery Davis et al. · Nature · 2016 · 2.5K citations · Full text

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Spine pruning drives antipsychotic-sensitive locomotion via circuit control of striatal dopamine

Il Hwan Kim, Mark A. Rossi, Dipendra K. Aryal et al. · Nature Neuroscience · 2015 · 128 citations · Full text

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Pruning recurrent neural networks replicates adolescent changes in working memory and reinforcement learning

Bruno B. Averbeck · Proceedings of the National Academy of Sciences · 2022 · 33 citations · Full text

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Disparate insults relevant to schizophrenia converge on impaired spike synchrony and weaker synaptic interactions in prefrontal local circuits

Jennifer L. Zick, David A. Crowe, Rachael K. Blackman et al. · Current Biology · 2021 · 18 citations · Full text

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A Critical Perspective on the Synaptic Pruning Hypothesis of Schizophrenia Pathogenesis

Matthew B. Johnson, Steven E. Hyman · Biological Psychiatry · 2022 · 16 citations

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