Concepedia

Schizophrenia-related Synaptic Pruning

Schizophrenia-Related Synaptic Pruning is a neurodevelopmental phenomenon characterized by excessive or dysregulated elimination of synaptic connections during adolescence and early adulthood, specifically associated with the pathophysiology of schizophrenia, distinguishing it from typical developmental synaptic pruning by its aberrant timing, regional specificity, and genetic underpinnings involving immune-related pathways such as complement-mediated pruning.

39

Publications

5.1K

Citations

275

Authors

117

Institutions

Publications per year

2017–2026

22

Parents

Publications

39

De novo mutations in schizophrenia implicate synaptic networks

Menachem Fromer, Andrew Pocklington, David H. Kavanagh et al. · Nature · 2014 · 1.7K citations · Full text

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Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Carl M. Sellgren, Jessica Gracias, Bradley Watmuff et al. · Nature Neuroscience · 2019 · 828 citations

, , +16

Disrupted-In-Schizophrenia 1 Regulates Integration of Newly Generated Neurons in the Adult Brain

Xin Duan, Jay Chang, Shaoyu Ge et al. · Cell · 2007 · 607 citations · Full text

, , +16

Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice

Melis Yilmaz, Esra Yalçın, Jessy Présumey et al. · Nature Neuroscience · 2020 · 329 citations · Full text

, , +17

Cortical Pruning and the Development of Schizophrenia: A Computer Model

Roy E. Hoffman, Steven K. Dobscha · Schizophrenia Bulletin · 1989 · 270 citations · Full text

, , +16

1–5 of 39

Authors

275

  1. SA
    Steven A. McCarroll

    Broad Institute, United States

    3 publications · 2.1K citations

    3

    h-index

  2. KN
    Kenneth N. Fish

    University of Pittsburgh, United States

    3 publications · 209 citations

    3

    h-index

  3. KM
    Konasale M. Prasad

    University of Pittsburgh, United States

    3 publications · 112 citations

    3

    h-index

  4. MB
    Matthew B. Johnson

    Boston Children's Hospital, United States

    2 publications · 44 citations

    2

    h-index

  5. DA
    David A. Lewis

    University of Pittsburgh, United States

    2 publications · 185 citations

    2

    h-index

1–5 of 275

Institutions

117

  1. Harvard University

    Cambridge, United States

    7 h-index

    41 publications

    11.9K citations

  2. University of Pittsburgh

    Pittsburgh, United States

    5 h-index

    14 publications

    638 citations

  3. Broad Institute

    Cambridge, United States

    4 h-index

    23 publications

    18.3K citations

  4. Boston Children's Hospital

    Boston, United States

    3 h-index

    19 publications

    2.6K citations

  5. Yale University

    New Haven, United States

    3 h-index

    4 publications

    369 citations

  6. VA Pittsburgh Healthcare System

    Pittsburgh, United States

    3 h-index

    14 publications

    1.6K citations

  7. McLean Hospital

    Belmont, United States

    3 h-index

    6 publications

    967 citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    2 h-index

    3 publications

    72 citations

1–8 of 117

Venues

  1. Biological Psychiatry

    4 publications · 105 citations

    4

    h-index

  2. Schizophrenia Bulletin

    3 publications · 327 citations

    3

    h-index

  3. American Journal of Psychiatry

    3 publications · 181 citations

    3

    h-index

  4. Cerebral Cortex

    2 publications · 168 citations

    2

    h-index

  5. Nature Neuroscience

    2 publications · 1.2K citations

    2

    h-index

1–5