Concepedia

Homeostatic Synaptic Pruning

Homeostatic Synaptic Pruning is a neurobiological process that belongs to the class of synaptic refinement mechanisms, distinguished by its role in maintaining neural circuit stability through the activity-dependent elimination of redundant or weak synaptic connections to preserve optimal neuronal function during neuroimmune tolerance.

5

Publications

4.6K

Citations

39

Authors

28

Institutions

Publications per year

2017–2026

3

Parents

Publications

5

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

Rosa Chiara Paolicelli, Giulia Bolasco, Francesca Pagani et al. · Science · 2011 · 4.2K citations

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Prenatal infection leads to ASD-like behavior and altered synaptic pruning in the mouse offspring

Lourdes Fernández de Cossío, Andrea S. Guzmán, Suzanne van der Veldt et al. · Brain Behavior and Immunity · 2016 · 215 citations

, , +16

Synaptic pruning through glial synapse engulfment upon motor learning

Yosuke M. Morizawa, Mami Matsumoto, Yuka Nakashima et al. · Nature Neuroscience · 2022 · 64 citations

, , +16

Unmasking Schizophrenia: Synaptic Pruning in Adolescence Reveals a Latent Physiological Vulnerability in Prefrontal Recurrent Networks

Matthew V. Chafee, Bruno B. Averbeck · Biological Psychiatry · 2022 · 24 citations · Full text

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A Critical Perspective on the Synaptic Pruning Hypothesis of Schizophrenia Pathogenesis

Matthew B. Johnson, Steven E. Hyman · Biological Psychiatry · 2022 · 16 citations

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1–5 of 5

Authors

39

  1. SK
    Schuichi Koizumi

    University of Yamanashi, Japan

    1 publications · 64 citations

    1

    h-index

  2. PP
    Patrizia Panzanelli

    University of Turin, Italy

    1 publications · 4.2K citations

    1

    h-index

  3. TF
    Tiago Ferreira

    McGill University, Canada

    1 publications · 4.2K citations

    1

    h-index

  4. TA
    Tomomi Aida

    Tokyo Medical and Dental University, Japan

    1 publications · 64 citations

    1

    h-index

  5. LF
    Lourdes Fernández de Cossío

    McGill University, Canada

    1 publications · 215 citations

    1

    h-index

1–5 of 39

Institutions

28

  1. National Institute of Mental Health

    Bethesda, United States

    1 h-index

    1 publications

    24 citations

  2. NutriNeuro

    Bordeaux, France

    1 h-index

    1 publications

    215 citations

  3. Harvard University

    Cambridge, United States

    1 h-index

    1 publications

    16 citations

  4. University of Turin

    Turin, Italy

    1 h-index

    2 publications

    8.5K citations

  5. Tokyo Medical and Dental University

    Tokyo, Japan

    1 h-index

    3 publications

    192 citations

  6. National Institute for Physiological Sciences

    Okazaki, Japan

    1 h-index

    2 publications

    128 citations

  7. University of Minnesota

    Minneapolis, United States

    1 h-index

    1 publications

    24 citations

  8. Senshu University

    Tokyo, Japan

    1 h-index

    1 publications

    64 citations

1–8 of 28

Venues

  1. Biological Psychiatry

    2 publications · 40 citations

    2

    h-index

  2. Nature Neuroscience

    1 publications · 64 citations

    1

    h-index

  3. Brain Behavior and Immunity

    1 publications · 215 citations

    1

    h-index

  4. Science

    1 publications · 4.2K citations

    1

    h-index

  5. CNS & Neurological Disorders - Drug Targets

    1 publications · 15 citations

1–5