A sensing strategy combining T7 promoter-contained DNA probe with CRISPR/Cas13a for detection of bacteria and human methyltransferase

Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands.

James G. Herman, Jeremy R. Graff, Sanna Myöhänen et al. · Proceedings of the National Academy of Sciences · 1996 · 5.6K citations · Full text

Epigenetic Change, Genetics, Dna Methylation +21

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.1K citations

Ssdna Molecules, Molecular Diagnostic Techniques, Engineering +14

Nucleic acid detection with CRISPR-Cas13a/C2c2

Jonathan S. Gootenberg, Omar O. Abudayyeh, Jeong Wook Lee et al. · Science · 2017 · 3.6K citations · Full text

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

Jonathan S. Gootenberg, Omar O. Abudayyeh, Max J. Kellner et al. · Science · 2018 · 2.5K citations · Full text

Engineering, Dna Analysis, Molecular Biology +18

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

Omar O. Abudayyeh, Jonathan S. Gootenberg, Silvana Konermann et al. · Science · 2016 · 2.3K citations · Full text