Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of <i>KRAS</i> ‐ <i>LKB1</i> co‐mutated lung cancer cells

Abstract

This study demonstrates that autophagy-derived acetyl-CoA promotes Snail acetylation and thereby facilitates invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells and that inhibition of the autophagy/acetyl-CoA/acetyl-Snail axis using CAMKK2 or ACLY inhibitors could be a potential therapeutic strategy to suppress metastasis of KL lung cancer.