Microbiology Spectrum · 2022 · 36 citations · 42 references
Life SciencesBioinformaticsMicrobiologyGenomicsMycologyNatural Product BiosynthesisBiosynthetic Gene ClustersFungal GeneticsFungal GenomicsFungal Natural Product BiosynthesisMicrobial Natural Product BiosynthesisPolyketide BiosynthesisBiosynthetic Gene Cluster AnalysisBiosynthetic Gene Cluster EvolutionFungal Polyketide BiosynthesisFungal Polyketide SynthasesGene Cluster AnnotationNatural Product Gene Cluster IdentificationPolyketide Synthase Gene ClustersPolyketide Synthase Gene Discovery
The implementation of natural products in the pharmaceutical industry relies on the possibility of modifying the natural product (NP) pathway to optimize yields and pharmacological effects. Characterization of genes and pathways underlying natural product biosynthesis is a major bottleneck for exploiting the medicinal properties of the natural products.
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BUSCO: assessing genome assembly and annotation completeness with single-copy orthologs
Felipe A. Simão, Robert M. Waterhouse, Panagiotis Ioannidis et al. · Bioinformatics · 2015 · 14.5K citations · Full text
Assembly of long, error-prone reads using repeat graphs
Mikhail Kolmogorov, Jeffrey Yuan, Yu Lin et al. · Nature Biotechnology · 2019 · 6.3K citations