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Using Human Induced Pluripotent Stem Cell–Derived Organoids to Identify New Pathologies in Patients With PDX1 Mutations

Mansa Krishnamurthy, Daniel O. Kechele, Taylor Broda, Xinghao Zhang, Jacob R. Enriquez, Heather A. McCauley, J. Guillermo Sanchez, Kyle W. McCracken, Joseph Palermo, Anas Bernieh,

Gastroenterology · 2022 · 24 citations · 21 references

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21

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.7K citations · Full text

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Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro

Jason R. Spence, Christopher N. Mayhew, Scott A. Rankin et al. · Nature · 2010 · 1.9K citations · Full text

, , +16

Evaluation of off-target and on-target scoring algorithms and integration into the guide RNA selection tool CRISPOR

Maximilian Haeussler, Kai Schönig, Hélène Eckert et al. · Genome biology · 2016 · 1.9K citations · Full text

, , +14

Insulin-promoter-factor 1 is required for pancreas development in mice

Jörgen Jönsson, Lena Carlsson, Helena Edlund · Nature · 1994 · 1.8K citations

, , +13

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

Martin F. Offield, Tom L. Jetton, Patricia A. Labosky et al. · Development · 1996 · 1.5K citations

, , +16