Dual CAR-T cells to treat cancers co-expressing NKG2D and PD1 ligands in xenograft models of peritoneal metastasis

Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo

Sarwish Rafiq, Oladapo Yeku, Hollie J. Jackson et al. · Nature Biotechnology · 2018 · 823 citations

Medicine, Immunology, Oncology +16

Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency

Judith Feucht, Jie Sun, Justin Eyquem et al. · Nature Medicine · 2018 · 543 citations · Full text

Life Sciences, Cell Biology, Immunology +10

A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors

Xiaojun Liu, Raghuveer Ranganathan, Shuguang Jiang et al. · Cancer Research · 2016 · 519 citations · Full text

Life Sciences, Immunology, Oncology +17

Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging

Roy L. Maute, Sydney R. Gordon, Aaron T. Mayer et al. · Proceedings of the National Academy of Sciences · 2015 · 353 citations · Full text

Pharmacy, Oncology, Pharmaceutical Biotechnology +17

Structure and Interactions of the Human Programmed Cell Death 1 Receptor

Xiaoxiao Cheng, Václav Veverka, Anand Radhakrishnan et al. · Journal of Biological Chemistry · 2013 · 332 citations · Full text

Life Sciences, Immunology, Molecular Biology +16