Concepedia

Novel protein kinase cAMP-Activated Catalytic Subunit Alpha (PRKACA) inhibitor shows anti-tumor activity in a fibrolamellar hepatocellular carcinoma model

Akiko Toyota, Megumi Goto, Masaya Miyamoto, Yoko Nagashima, Shiho Iwasaki, Takahiro Komatsu, Takayuki Momose, Keisuke Yoshida, Tomoharu Tsukada, Tetsuyoshi Matsufuji,

Biochemical and Biophysical Research Communications · 2022 · 17 citations · 9 references

DOI

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References

9

Detection of a Recurrent <i>DNAJB1-PRKACA</i> Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

Joshua N. Honeyman, Elana P. Simon, Nicolas Robine et al. · Science · 2014 · 493 citations

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Patient-derived xenografts effectively capture responses to oncology therapy in a heterogeneous cohort of patients with solid tumors

Eugene Izumchenko, K. Paz, Daniel Ciznadija et al. · Annals of Oncology · 2017 · 337 citations · Full text

, , +7

DNAJB1-PRKACA is specific for fibrolamellar carcinoma

Rondell P. Graham, Long Jin, Darlene L. Knutson et al. · Modern Pathology · 2015 · 183 citations · Full text

, , +17

<i>DNAJB1–PRKACA</i> fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

Edward R. Kastenhuber, Gadi Lalazar, Shauna L Houlihan et al. · Proceedings of the National Academy of Sciences · 2017 · 162 citations · Full text

, , +17

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct

Aatur D. Singhi, Laura D. Wood, Michael Torbenson et al. · Gastroenterology · 2019 · 157 citations · Full text

, , +17