Edward R. Kastenhuber

An atlas of substrate specificities for the human serine/threonine kinome

Jared L. Johnson, Tomer M. Yaron, Emily M. Huntsman et al. · Nature · 2023 · 621 citations · Full text

Inducible in vivo genome editing with CRISPR-Cas9

Lukas E. Dow, Jonathan Fisher, Kevin P. O’Rourke et al. · Nature Biotechnology · 2015 · 499 citations · Full text

Vivo Genome, In Vivo Gene Therapy, Natural Sciences +7

p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression

Sung‐Hwan Moon, Chun‐Hao Huang, Shauna L Houlihan et al. · Cell · 2018 · 442 citations · Full text

Medicine, Mevalonate Pathway, Tumor Suppressor +4

Optimized base editors enable efficient editing in cells, organoids and mice

María Paz Zafra, Emma M. Schatoff, Alyna Katti et al. · Nature Biotechnology · 2018 · 347 citations · Full text

Engineering, Genome Surgery, Medicine +10

Disruption of CRAF-Mediated MEK Activation Is Required for Effective MEK Inhibition in KRAS Mutant Tumors

Piro Lito, Anna Saborowski, Jingyin Yue et al. · Cancer Cell · 2014 · 304 citations · Full text

Effective Mek Inhibition, Kras Mutant Tumors, Signaling Pathway +9