Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

Kun Liu, Enpeng Zhao, Ghulam Ilyas, +5

Autophagy

MitophagyImmunologyImmune RegulationInnate ImmunityInflammation +16

<i>DNAJB1–PRKACA</i> fusion kinase interacts with β-catenin and the liver regenerative response to drive fibrolamellar hepatocellular carcinoma

Edward R. Kastenhuber, Gadi Lalazar, Shauna L Houlihan, +9

Proceedings of the National Academy of Sciences

Transcriptomic characterization of fibrolamellar hepatocellular carcinoma

Elana P. Simon, Catherine A. Freije, Benjamin A. Farber, +10

Proceedings of the National Academy of Sciences

β-Glucosylceramide: a novel method for enhancement of natural killer T lymphoycte plasticity in murine models of immune-mediated disorders

Ehud Zigmond, Sarah Preston, Orit Pappo, +7

Gut

Oral Administration of OKT3 MAb to Patients with NASH, Promotes Regulatory T-cell Induction, and Alleviates Insulin Resistance: Results of a Phase IIa Blinded Placebo-Controlled Trial

Gadi Lalazar, Meir Mizrahi, Ilit Turgeman, +12

Journal of Clinical Immunology

Autoimmune DiseaseInsulin ManagementDiabetesImmunologyT-regulatory Cell +7

Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH

Ami Ben Yaʼacov, Meir Mizrahi, Yehudit Shabat, +6

Journal of Inflammation Research

Oral administration of immunoglobulin G-enhanced colostrum alleviates insulin resistance and liver injury and is associated with alterations in natural killer T cells

Tomer Adar, Gadi Lalazar, Yoav Lichtenstein, +6

Clinical & Experimental Immunology

ImmunologyImmune RegulationPathologyImmunotherapeuticsNatural Killer T +16

β-Glycosphingolipids improve glucose intolerance and hepatic steatosis of the Cohen diabetic rat

Ehud Zigmond, Sarah W. Zangen, Orit Pappo, +5

American Journal of Physiology-Endocrinology and Metabolism

GlycobiologyImmunologyNatural Killer TGlucose ToleranceImmune System +18

Oral Administration of OKT3 Monoclonal Antibody to Human Subjects Induces a Dose-Dependent Immunologic Effect in T Cells and Dendritic Cells

Yaron Ilan, Ehud Zigmond, Gadi Lalazar, +17

Journal of Clinical Immunology

Okt3 Monoclonal AntibodyAutoimmune DiseaseT-regulatory CellImmunologyImmunologic Mechanism +7

A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing

James A. Saltsman, William J. Hammond, Nicole J.C. Narayan, +6

Cancers

PathologyCancer BiologyHuman Organoid ModelTumor BiologyHepatobiliary Tumor +20