Concepedia

Ginsenoside Rg1 promotes remyelination and functional recovery in demyelinating disease by enhancing oligodendrocyte precursor cells-mediated myelin repair

Li Liu, Xinke Du, Qing Yang, Manjing Li, Qingsen Ran, Qingwu Liu, Lina Yang, Lisong Sun, Yuxuan Guo, Yujie Li,

Phytomedicine · 2022 · 27 citations · 20 references

DOIFull text

Open access

Abstract

By paving the way for OPCs differentiation, Rg1 could maintain the integrity of myelin and is a promising candidate for functional recovery in demyelinating diseases.

References

20

Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNS

Stephen P.J. Fancy, Sergio E. Baranzini, Chao Zhao et al. · Genes & Development · 2009 · 625 citations · Full text

Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study

Peter Connick, Madhan Kolappan, Charles Crawley et al. · The Lancet Neurology · 2012 · 602 citations · Full text

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

Antoine Lampron, Antoine Larochelle, Nathalie Laflamme et al. · The Journal of Experimental Medicine · 2015 · 583 citations · Full text

Demyelination Causes Adult CNS Progenitors to Revert to an Immature State and Express Immune Cues That Support Their Migration

Sarah Moyon, Anne‐Laure Dubessy, Marie Stéphane Aigrot et al. · Journal of Neuroscience · 2015 · 283 citations · Full text

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Extensive remyelination of the CNS leads to functional recovery

I. D. Duncan, Alexandra Brower, Yoichi Kondo et al. · Proceedings of the National Academy of Sciences · 2009 · 225 citations · Full text

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