iScience · 2022 · 27 citations · 26 references
Life SciencesMolecular BiologyMolecular GeneticsGene ExpressionTranscriptionTranscriptional RegulationLipid MetabolismLipoprotein MetabolismNuclear ReceptorsRna-binding ProteinsTriacylglycerol MetabolismTriglyceride MetabolismHepatic Lipid AccumulationHepatic Triglyceride MetabolismLipid Metabolism EffectsLipid Metabolism Gene ExpressionLipid Metabolism PathwaysLipoprotein Metabolism RegulationLipoprotein ReceptorsMrna Stability Control
mRNA at the post-transcription level. In conclusion, our study demonstrates that increased LDLR transcription and mRNA stability is regulated by SREBP2 directly or indirectly, and promotes hepatic TG accumulation by endocytosing LDL in fish.
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