An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy

Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

Martin Lundqvist, Johannes Stigler, Giuliano Elia et al. · Proceedings of the National Academy of Sciences · 2008 · 3K citations · Full text

Natural Sciences, Biochemistry, Biophysics +17

Rational design of cationic lipids for siRNA delivery

Sean C. Semple, Akin Akinc, Jianxin Chen et al. · Nature Biotechnology · 2010 · 1.8K citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +16

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Jérôme Gilleron, William Querbes, Anja Zeigerer et al. · Nature Biotechnology · 2013 · 1.6K citations

Pharmacy, Molecular Pharmaceutics, Pharmaceutics +17

Effect of Nivolumab vs Bevacizumab in Patients With Recurrent Glioblastoma

David A. Reardon, Alba A. Brandes, Antonio Omuro et al. · JAMA Oncology · 2020 · 1.5K citations · Full text

Medicine, Oncology, Pharmacotherapy +17

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells.

Tamotsu Yoshimori, Akira Yamamoto, Yoshinori Moriyama et al. · Journal of Biological Chemistry · 1991 · 1.4K citations · Full text

Life Sciences, Biochemistry, Cell Biology +14