EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma

Abstract

Ewing sarcoma tumors are comprised of tumor cells that exist along a mesenchymal transcriptional continuum. The identity of cells along this continuum is, in large part, determined by the competing activities of EWS::FLI1 and HOXD13. See related commentary by Weiss and Bailey, p. 4360.