Rapid RNA detection through intra-enzyme chain replacement-promoted Cas13a cascade cyclic reaction without amplification

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

Rodolphe Barrangou, Christophe Fremaux, Hélène Deveau et al. · Science · 2007 · 6.2K citations

Phage-resistance Phenotype, Genetics, Bacteriophage +12

CRISPR-Cas12a target binding unleashes indiscriminate single-stranded DNase activity

Janice S. Chen, Enbo Ma, Lucas B. Harrington et al. · Science · 2018 · 4.1K citations

Ssdna Molecules, Molecular Diagnostic Techniques, Engineering +14

Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6

Jonathan S. Gootenberg, Omar O. Abudayyeh, Max J. Kellner et al. · Science · 2018 · 2.5K citations · Full text

Engineering, Dna Analysis, Molecular Biology +18

Field-deployable viral diagnostics using CRISPR-Cas13

Cameron Myhrvold, Catherine A. Freije, Jonathan S. Gootenberg et al. · Science · 2018 · 1.4K citations · Full text

Two distinct RNase activities of CRISPR-C2c2 enable guide-RNA processing and RNA detection

Alexandra East-Seletsky, Mitchell R. O’Connell, Spencer C. Knight et al. · Nature · 2016 · 1.2K citations · Full text

Rna Processing, Natural Sciences, Molecular Biology +9