Concepedia

The ORF7a protein of SARS-CoV-2 initiates autophagy and limits autophagosome-lysosome fusion via degradation of SNAP29 to promote virus replication

Peili Hou, Xuefeng Wang, Hongmei Wang, Tiecheng Wang, Zhangping Yu, Chunqing Xu, Yudong Zhao, Wenqi Wang, Yong Zhao, Fengyun Chu,

Autophagy · 2022 · 134 citations · 45 references

DOIFull text

Open access

Concepts

Abstract

: tissue culture infectious dose; TEM: transmission electron microscopy; TUBB, tubulin, beta; ULK1: unc-51 like autophagy activating kinase 1.

References

45

A Novel Coronavirus from Patients with Pneumonia in China, 2019

Na Zhu, Dingyu Zhang, Xingwang Li et al. · New England Journal of Medicine · 2020 · 30.4K citations · Full text

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Pathological findings of COVID-19 associated with acute respiratory distress syndrome

Zhe Xu, Lei Shi, Yijin Wang et al. · The Lancet Respiratory Medicine · 2020 · 8.9K citations · Full text

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, Mondira Kundu, Benoı̂t Viollet et al. · Nature Cell Biology · 2011 · 7K citations · Full text

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Autophagy in the Pathogenesis of Disease

Beth Levine, Guido Kroemer · Cell · 2008 · 7K citations · Full text

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Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury.

Changmeng Cui, Jianzhong Cui, Feng Jin et al. · PubMed · 2017 · 5.2K citations

, , +12