RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation

cGAS surveillance of micronuclei links genome instability to innate immunity

Karen J. Mackenzie, Paula Carroll, Carol-Anne Martin et al. · Nature · 2017 · 1.6K citations · Full text

Chromatin, Systems Biology, Genetics +8

Human Senataxin Resolves RNA/DNA Hybrids Formed at Transcriptional Pause Sites to Promote Xrn2-Dependent Termination

Konstantina Skourti-Stathaki, Nicholas Proudfoot, Natalia Gromak · Molecular Cell · 2011 · 792 citations · Full text

Cotranscriptionally Formed DNA:RNA Hybrids Mediate Transcription Elongation Impairment and Transcription-Associated Recombination

Pablo Huertas, Andrés Aguilera · Molecular Cell · 2003 · 749 citations · Full text

Transcription-associated Recombination, Transcriptional Regulation, Natural Sciences +9

Exploring RNA transcription and turnover <i>in vivo</i> by using click chemistry

Cindy Y. Jao, Adrian Salic · Proceedings of the National Academy of Sciences · 2008 · 710 citations · Full text

Molecular Biology, Total Rna, Click Chemistry +16

DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity

Anetta Härtlová, Saskia F. Erttmann, Faizal A.M. Raffi et al. · Immunity · 2015 · 695 citations · Full text

Host Response, Dna Damage, Anti-microbial Innate Immunity +9