Combined induction of mTOR-dependent and mTOR-independent pathways of autophagy activation as an experimental therapy for Alzheimer's disease-like pathology in a mouse model

The role of autophagy in neurodegenerative disease

Ralph A. Nixon · Nature Medicine · 2013 · 2K citations

Life Sciences, Cell Biology, Neuroscience +12

Trehalose, a Novel mTOR-independent Autophagy Enhancer, Accelerates the Clearance of Mutant Huntingtin and α-Synuclein

Sovan Sarkar, J. Eric Davies, Zebo Huang et al. · Journal of Biological Chemistry · 2006 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

Barry Boland, Ashok Kumar, Sarah Lee et al. · Journal of Neuroscience · 2008 · 1.1K citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

Patricia Spilman, Natalia Podlutskaya, Matthew J. Hart et al. · PLoS ONE · 2010 · 1K citations · Full text

Life Sciences, Neuroscience, Pharmacology +17

Pathogenic Lysosomal Depletion in Parkinson's Disease

Benjamin Dehay, Jordi Bové, Natalia Rodríguez‐Muela et al. · Journal of Neuroscience · 2010 · 804 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17