Protective Role of Rosemary Ethanolic Extract on Thioacetamide Induced Hepatic Encephalopathy: Biochemical and Molecular Studies

Abstract

Hepatic encephalopathy is a profound systemic consequence of liver insufficiency with neuropsychiatric symptoms, and in severe cases, coma and death developed The mortality rate of HE ranging from 50-90% of patients allover the world Normally, the liver can detoxify endogenous and exogenous ammonia into urea. Once the liver fails, hyperammonemia occurs, and ammonia passes the blood-brain barrier Glutamine synthase catalyze the synthesis of glutamine which accumulates inside astrocytes leading to cerebral edema and intracranial hypertension with subsequent alterations in cerebral functions