[(Cp‐R)M(CO)₃] (M=Re or ^99mTc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX

Abstract

Verbesserte Rezeptorselektivität: Carboanhydrase-Hemmstoffe sind wichtig für die Krebsdiagnostik und -therapie. Mit einer Kombination aus nicht radioaktiven Re-Verbindungen und ihren radioaktiven 99mTc-Homologen sind Therapie und Bildgebung (Theragnostik) möglich. Die Synthese und In-vitro-Untersuchung des Komplexes [(Cp-R)M(CO)3] (Cp=Cyclopentadienyl; M=Re, 99mTc), der einen Carboanhydrase-Zielvektor R trägt, werden vorgestellt (siehe Bild). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.