Ferrocene‐Mediated Proton‐Coupled Electron Transfer in a Series of Ferrocifen‐Type Breast‐Cancer Drug Candidates

Abstract

A double-barreled approach: The addition of ferrocene to an antiestrogen drug skeleton was found to induce cytotoxicity towards breast-cancer cells that are resistant to the common antiestrogen drug. The efficacy of this drug has been related to the proton-coupled electron transfer observed in the presence of pyridine as a base (see picture).