Use of isogenic human cancer cells for high-throughput screening and drug discovery

Activity of a Specific Inhibitor of the BCR-ABL Tyrosine Kinase in the Blast Crisis of Chronic Myeloid Leukemia and Acute Lymphoblastic Leukemia with the Philadelphia Chromosome

Brian Druker, Charles L. Sawyers, Hagop M. Kantarjian et al. · New England Journal of Medicine · 2001 · 2.7K citations · Full text

Medicine, Hematology, Oncology +17

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

Ana Cuenda, J.B. Rouse, Yair N. Doza et al. · FEBS Letters · 1995 · 2.1K citations

Life Sciences, Molecular Biology, Pharmacology +14

Altered Growth of Human Colon Cancer Cell Lines Disrupted at Activated Ki- <i>ras</i>

Senji Shirasawa, Masanori Furuse, Nobuhiko Yokoyama et al. · Science · 1993 · 627 citations

Medicine, Genetics, Oncology +17

Use of a screen for synthetic lethal and multicopy suppressee mutants to identify two new genes involved in morphogenesis in Saccharomyces cerevisiae.

Alan Bender, John R. Pringle · Molecular and Cellular Biology · 1991 · 440 citations · Full text

Life Sciences, Genetics, Molecular Genetics +13

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Nigel J. Liverton, John W. Butcher, Christopher F. Claiborne et al. · Journal of Medicinal Chemistry · 1999 · 196 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17