Angewandte Chemie · 2005 · 37 citations · 11 references
PharmacyMedicinal ChemistryPharmacologyCancer PharmacologyChemotherapyDrug DiscoveryAnticancer Prodrug DesignEnzyme InhibitionProdrug Activation MechanismsCatalytic Reaction MechanismsCatalytic Reaction SelectivityChemotherapeutic Prodrug DesignCollapseProdrug SelectivitySelective Cancer Therapy
Der Dominoeffekt einer einzigen enzymkatalysierten Reaktion an einer Prodrug-Plattform leitet den sequenziellen Kollaps des gesamten Systems ein und setzt so die aktiven Wirkstoffeinheiten frei (siehe Schema). Solche dendritischen Systeme könnten zur Verbesserung selektiver chemotherapeutischer Methoden in der Krebstherapie führen. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z461657_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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A cytotoxic agent can be generated selectively at cancer sites
K D Bagshawe, Springer Cj, F Searle et al. · British Journal of Cancer · 1988 · 265 citations · Full text
Medicine, Cancer Biology, Oncology +11