Raman Spectroscopy of Biological Tissues

TLDR

Raman spectroscopy peaks are largely consistent across different methods, showing similar definitions for identical spectral regions. The article reviews recent advances in Raman spectroscopy of natural tissues and cell biology and aims to create a database of molecular fingerprints to aid researchers in identifying key peak frequencies. It compiles the most widely used peak frequencies and their assignments, forming a reference database of molecular fingerprints. The database is expected to improve the quantity and quality of spectral data, and this review is the first to provide a precise collection of key Raman peak frequencies, especially useful for cancer tissue analysis.

Abstract

Abstract This article reviews some of the recent advances in Raman spectroscopy, in areas related to natural tissues and cell biology. It summarizes some of the most widely used peak frequencies and their assignments. The aim of this study is to prepare a database of molecular fingerprints, which will help researchers in defining the chemical structure of the biological tissues introducing most of the important peaks present in the natural tissues. In spite of applying different methods, there seems to be a considerable similarity in defining the peaks of identical areas of the spectra. As a result, it is believed that preparing a unique collection of the frequencies encountered in Raman spectroscopic studies can lead to significant improvements both in the quantity and quality of spectral data and their outcomes. This article is the first review of its kind to provide a precise database on the most important Raman characteristic peak frequencies for researchers aiming to analyze natural tissues by Raman spectroscopy and will especially be of considerable assistance to those who are focusing on the analysis of cancerous tissues by Raman spectroscopy.