Concepedia

A functional interplay between intein and extein sequences in protein splicing compensates for the essential block B histidine

Kristina Friedel, Monika A. Popp, Julian C. J. Matern, Emerich Mihai Gazdag, Ilka V. Thiel, Gerrit Volkmann, Wulf Blankenfeldt, Henning D. Mootz

Chemical Science · 2018 · 36 citations · 48 references

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Concepts

Abstract

Steric bulk can compensate for a catalytically critical histidine in an intein's active site and promote the N–S acyl shift.

References

48

The Protein Data Bank

Helen M. Berman · Nucleic Acids Research · 2000 · 39.8K citations

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Features and development of <i>Coot</i>

Paul Emsley, Bernhard Lohkamp, W. G. Scott et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 29.6K citations · Full text

, , +16

<i>PHENIX</i>: a comprehensive Python-based system for macromolecular structure solution

Paul D. Adams, Pavel V. Afonine, G. Bunkóczi et al. · Acta Crystallographica Section D Biological Crystallography · 2010 · 24.5K citations · Full text

, , +16

<i>Phaser</i>crystallographic software

Airlie J. McCoy, Ralf W. Grosse‐Kunstleve, Paul D. Adams et al. · Journal of Applied Crystallography · 2007 · 20.9K citations · Full text

, , +16

<i>XDS</i>

Wolfgang Kabsch · Acta Crystallographica Section D Biological Crystallography · 2010 · 16.9K citations · Full text

, , +13