Inhibitory Effect of Polyphenols Extracts from Peanut Shells on the Activity of Pancreatic Lipase in vitro

Abstract

Obesity is a major health problem worldwide and is associated with several pathological disorders, such as diabetes, cardiovascular disease and cancer. Lipase inhibition is one of the main therapies for obesity. Recent studies have shown the role of polyphenols in the prevention of obesity and obesity-related chronic diseases. Here, we evaluated the ability of polyphenol-rich extracts from peanut shell to inhibit pancreatic lipase activity in vitro. The results showed that the inhibition ratio of polyphenols extracts from peanut shells (PPS) on lipase can reached 41.5 % at 0.29 mg/mL. And the inhibition type of polyphenols extracts from peanut shells against pancreatic lipase is competitive inhibition. The inhibition constant Ki was 0.16 mg/mL. Therefore, polyphenols extracts from peanut shells may be useful in treatment of obesity.