Stage IV Pancreatic Cancer Patient Treated With FOLFIRINOX Combined With Oral Methioninase: A Highly-Rare Case With Long-term Stable Disease

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

Thierry Conroy, Françoise Desseigne, Marc Ychou et al. · New England Journal of Medicine · 2011 · 7.6K citations · Full text

Methionine is a metabolic dependency of tumor-initiating cells

Zhenxun Wang, Lian Yee Yip, Jia Hui Jane Lee et al. · Nature Medicine · 2019 · 380 citations

Medicine, Metabolic Remodeling, Metabolic Dependency +5

High in vivo rates of methionine biosynthesis in transformed human and malignant rat cells auxotrophic for methionine.

Robert M. Hoffman, Richard W. Erbe · Proceedings of the National Academy of Sciences · 1976 · 297 citations

Biosynthesis, Malignant Rat Cells, Biochemistry +11

The metabolic defect of methionine dependence occurs frequently in human tumor cell lines

James O. Mecham, David H. Rowitch, Christine Wallace et al. · Biochemical and Biophysical Research Communications · 1983 · 241 citations

Tumor Biology, Metabolic Defect, Biochemistry +9

Altered methionine metabolism occurs in all members of a set of diverse human tumor cell lines

P Stern, Christine Wallace, Robert M. Hoffman · Journal of Cellular Physiology · 1984 · 198 citations