Journal of Heterocyclic Chemistry · 2022 · 12 citations · 7 references
Natural SciencesChemistryMedicinal ChemistryDrug DiscoveryHerbicide ChemistryOrganic ChemistryAromatic PlantsHerbicide Structure-activity RelationshipsHerbicide SynthesisHeterocyclic ChemistryHerbicidal BioassaysHerbicidal SelectivityHeterocyclic AromaticityHeterocyclic Herbicide SynthesisStructure-based Herbicide Design
Abstract In order to find new heterocyclic compounds with high herbicidal activity, a series of novel 2‐phenylpyridine derivatives were designed and synthesized by incorporating alkenyl into 2‐phenylpyridine moieties. The structures of the title compounds were characterized by 1 H NMR, 13 C NMR, 19 F NMR, and HRMS. The herbicidal activities assay demonstrated that most of the title compounds showed 100% inhibition against Abutilon theophrasti and Amaranthus retroflexus at 150 g a.i./ha. At 37.5 g a.i./ha, compounds 6f and 6g exhibited comparable inhibition (>80%) against Abutilon theophrasti , Amaranthus retroflexus , and Eclipta prostrate , when compared with the positive control mesotrione at 150 g a.i./ha.
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James B. Murray, Stephen D. Roughley, Natalia Matassova et al. · Journal of Medicinal Chemistry · 2014 · 78 citations